RISK PREDICTION SCORES OF DISEASES
نویسندگان
چکیده
منابع مشابه
Multiethnic polygenic risk scores improve risk prediction in diverse populations.
Methods for genetic risk prediction have been widely investigated in recent years. However, most available training data involves European samples, and it is currently unclear how to accurately predict disease risk in other populations. Previous studies have used either training data from European samples in large sample size or training data from the target population in small sample size, but...
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The only approved clot-busting medical treatment in ischemic stroke, intravenous thrombolysis (IVT), is not without complications. One of the major reasons for withholding the therapy remains fear of symptomatic intracranial hemorrhage (sICH), which can worsen patients’ outcomes. The number needed for IVT to cause fatal sICH is 36.5, and to cause any worsening of outcome (≥1 grade on modified R...
متن کاملMultilocus genetic risk scores for coronary heart disease prediction.
OBJECTIVE Current guidelines do not support the use of genetic profiles in risk assessment of coronary heart disease (CHD). However, new single nucleotide polymorphisms associated with CHD and intermediate cardiovascular traits have recently been discovered. We aimed to compare several multilocus genetic risk score (MGRS) in terms of association with CHD and to evaluate clinical use. APPROACH...
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Many in-hospital mortality risk prediction scores dichotomize predictive variables to simplify the score calculation. However, hard thresholding in these additive stepwise scores of the form "add x points if variable v is above/below threshold t" may lead to critical failures. In this paper, we seek to develop risk prediction scores that preserve clinical knowledge embedded in features and stru...
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ژورنال
عنوان ژورنال: Complex Issues of Cardiovascular Diseases
سال: 2018
ISSN: 2587-9537,2306-1278
DOI: 10.17802/2306-1278-2018-7-1-84-93